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A New Age For Genetic Testing

Experts in the field of human genetics predict the growth of personalised medicine, as patients increasingly take control of their health – and medical practitioners aim to prescribe more accurate and effective treatment.

Individuals seeking (or those on) medical treatment can be genetically tested as a means of tailoring treatment for better outcomes.

Precision is power

Personalised medicine is underpinned by pharmacogenomics – the study of genetic variation that determines how individuals respond to certain drugs and how those drugs are metabolised in the body. Also known as “precision medicine”, personalised medicine gives medical practitioners the power to accurately determine the right drug and dose for the patient, based on their DNA.

How it works

With advancements in the field of pharmacogenomics, the process of genetic testing has become increasingly simple and user-friendly. Genetic tests available in South Africa now include those as simple as a cheek swab done in the comfort of the patient’s own home – countering the perception that genetic testing is invasive, complicated or excessively expensive.

Experts weigh in

Dr Daniel Meyersfeld, molecular biologist and founder of DNAlysis Biotechnology, suggests extensive research conducted over the past few years supports genotype testing as means of determining patient-specific precision medicine.

“Medicine is no longer ‘one dose fits all’. By analysing DNA, it’s possible to understand how different genotypes affect the metabolism of medication in the body,” explains Meyersfeld. “With these scientific insights, medical practitioners can pre-emptively optimise medications for their patient and see better results by avoiding a ‘trial-and-error’ approach to drug prescription.”

Mind the (knowledge) gap

“In SA, there’s a misconception that genetic testing is hugely expensive and invasive, which simply isn’t the truth. There’s also a fear of genetic information falling into the wrong hands – being used by insurance companies to determine risk, for example,” says Meyersfeld. “Tests like mygeneRx are couriered to a lab to be tested. The results are strictly confidential and only shared with the nominated healthcare practitioner.”

He adds, “The cost, when weighed up with the lifetime benefits of accurate and safe medical treatment, is almost negligible. Not to mention patients will actually save money in the long run by avoiding medications that don’t work.”

Meds to watch

“Currently, drugs are prescribed to meet the needs of the general population – not the individual,” says Meyersfeld. Areas of particular focus for genetic testing and personalised medicine include cardiovascular disease, psychiatry and pain management, as these clusters are frequently prescribed as chronic medications.

Clopidogrel, as an example, is the standard treatment to stop blood clotting, heart attacks or strokes after coronary stent surgery – but studies show 2 to 14% of the population don’t metabolise the medication adequately, which can leave them vulnerable. Widely used blood-thinner Warfarin is also known to vary in effectiveness from patient to patient, which makes dosing problematic for medical practitioners.

Harnessing healthcare

Meyersfeld urges South Africans to discuss genetic testing with their medical practitioner, and take control of their healthcare. “We’re in the information age on steroids. There’s nothing we can’t know these days. So why do we know so little about our own DNA? It’s the roadmap for how our bodies work, so it makes sense for individuals – and their trusted medical practitioners – to understand everything about their unique genetics, so they can access more informed, more effective medical treatment,” concludes Meyersfeld.

mygeneRx, the latest addition to the DNAlysis Biotechnology portfolio, analyses genotypes associated with drug responsiveness for cardiovascular disease, psychiatry and pain management. To find out more about DNAlysis Biotechnology, visit www.dnalysis.co.za.

Source and Image: DNAlysis Biotechnology.

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